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KMID : 0043320110340060907
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Archives of Pharmacal Research
2011 Volume.34 No. 6 p.907 ~ p.912
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Aromatic compounds from the halotolerant fungal strain of Wallemia sebi PXP-89 in a hypersaline medium
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Peng Xiao Ping
Wang Yi
Liu Pei Pei
Hong Kui
Chen Hao
Yin Xia
Zhu Wei Ming
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Abstract
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A new cyclopentanopyridine alkaloid, 3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (1), together with 11 known aromatic compounds were isolated from the secondary metabolites of the halotolerant fungal strain Wallemia sebi PXP-89 in 10% NaCl. Their structures including the absolute configurations of (2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (2), (2R,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (3), and (S)-3-hydroxy-4-(4-hydroxyphenyl)-2-one (4) were elucidated by spectroscopic analysis and a modified Mosher’s method. Compound 1 exhibited antimicrobial activity against Enterobacter aerogenes with a MIC of 76.7 μM. The absolute configurations of compounds 2?4 were determined for the first time.
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KEYWORD
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Halotolerant fungus, Wallemia sebi, Antibacterial activity, Cyclopentanopyridine alkaloid
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